This webinar explores how real-world data (RWD) and AI are transforming clinical development, evidence generation, and commercialization, particularly in rare diseases and brain cancer. Speakers discuss how integrated RWD helps identify geographically dispersed patients, optimize trial design, support biomarker-driven targeting, and improve commercial strategy, while AI and NLP enable deeper analysis of unstructured clinical data and patient journeys. The session also highlights the future potential of synthetic control arms, personalized therapies, and data-driven approaches to accelerate innovation and improve outcomes for patients with high unmet need.